Thursday, July 27, 2006

Protein-protein interactions from evolutionary information

Protein interactions are key for understanding the functions of genes and proteins.

Multiple sequence alignments are rich sources of evolutionary information: conserved positions in structural cores and active sites; family-dependent conservation (tree determinants); coevolution (correlated mutations).

Sequence-based methods for prediction of interacting regions
  • Tree-Determinant Residues and interacting surfaces,
  • Correlated mutations: can point to the residues and regions implicated in the interaction between the two proteins,
Hybrid methods use both structure (docking) and sequence information: neural networks.

Computational methods based on genomic information:
  • Phlyogenetic Profiles,
  • Conservation of Gene Neighboring,
  • Gene Fusion: related to presence of fused genes in various genomes,
Computational methods based on sequence information:
  • Correlated Mutations (i2h),
  • Similarity of Phylogenetic Trees (mirrortree).

[+/-] show/hide this post  

3 Comments:

At 4:12 PM, Blogger dronbyfoto said...

Keep up the good work. thnx!
»

 
At 2:53 AM, Blogger newloghere said...

I really enjoyed looking at your site, I found it very helpful indeed, keep up the good work.
»

 
At 4:21 AM, Blogger mobilemob said...

Greets to the webmaster of this wonderful site. Keep working. Thank you.
»

 

Post a Comment

<< Home